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KMID : 0377619760310040375
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Korean Jungang Medical Journal
1976 Volume.31 No. 4 p.375 ~ p.393
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Effects of Psychotropic Drugs on the Prolactin Secretion in Rats An Immunohistochemical Study
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Abstract
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The effects of several psychotropic drugs on the prolactin release in rats were studied histologically and immunohistochemically. Estradiol primed virgin rats were administered with perphenazine(1mg and 8mg/day), inzipramine(1mg and 8mg/day) and reserpine (0.1mg and 0.2mg/day) respectively- for 5 days. Paraffin sections of pituitary glands were stained with anti-prolactin and antiRGB-peroxidase immunohistochemically and other organs were studied by ordinary H-E stain. Through the prolactin- cell counts in pituitary glands and other histological observation, the following results were obtained.
Administration of perphenazine and reserpine induced noticeable decrease on prolactin cell counts as well as reduction of staining intensities. While imipramine, injected rats had little effects on prolactin release. The most high cell counts were found in control groups that would be an evidence of intact hormone status. No obvious differences appeared between low doses and high doses administration in each groups.
Marked effects on mammary glands after administration of perphenazine and reserpine were resulted while that of control groups revealed no evidence of development in duct system and acini.
In ovaries of experimental groups, apparent features of well developed corpus luteum appeared by the injection of psychotropic drugs with the exception of animals in group III which gave no altered features to that of control group.
There were also significant increase in weight of pituitary glands, ovaries
And adrenal glands in reserpine treated animals.
The above results strongly suggest that the injection of psychotrogic drugs can induce higher level of prolactin secretion even in virgin rats and consequently it effect to the mammary glands and ovaries for lactogenesis and luteo tropic fiction respectively.
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KEYWORD
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